NCLEX Exam NCLEX-PN Topic 1 Question 5 Discussion

Actual exam question for NCLEX's NCLEX-PN exam

Question #: 5
Topic #: 1

[All NCLEX-PN Questions]

The chemotherapeutic DNA alkylating agents such as nitrogen mustards are effective because they:

Across-link DNA strands with covalent bonds between alkyl groups on the drug and guanine bases on DNA.

Bhave few, if any, side effects.

Care used to treat multiple types of cancer.

Dare cell-cycle-specific agents.

Show Suggested Answer

Suggested Answer: A

Alkylating agents are highly reactive chemicals that introduce alkyl radicals into biologically active molecules

and thereby prevent their proper functioning, replication, and transcription. Choice 2 is incorrect because alkylating

agents have numerous side effects including alopecia, nausea, vomiting, and myelosuppression. Choice 3 is incorrect because nitrogen mustards have a broad spectrum of activity against chronic lymphocytic leukemia, non-Hodgkin's lymphoma, and breast and ovarian cancer, but they are effective chemotherapeutic agents because of DNA crosslinkage. Choice 4 is incorrect because alkylating agents are non-cell-cycle-specific agents.PharmacologicalTherapies

by Lajuana at Jun 12, 2025, 08:59 PM

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Alfreda

5 days ago

I think the answer is A.

upvoted 0 times

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