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NABP Exam NAPLEX Topic 2 Question 67 Discussion

Actual exam question for NABP's NAPLEX exam
Question #: 67
Topic #: 2
[All NAPLEX Questions]

Your patient is a 58-year-old male who presents with onset of severe substernal chest pain and shortness of breath. An ECG reveals an acute STEMI, and he is on his way to the cardiac catheterization suite for percutaneous coronary intervention.

Which of the following drugs used in acute coronary syndromes treated with PCI must undergo oxidation by hepatic P450 enzymes to an active form?

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Suggested Answer: A

Benign prostatic hyperplasia (BPH) is an example of postrenal acute kidney injury (AKI). Postrenal AKI, as the name suggests, involves an effect 'post' or 'beyond' the kidney, to problems that emerge downstream from the kidney. BPH is one such example of that. Other examples include kidney stones, bladder stones and bladder cancer.


by Tiera at Aug 08, 2023, 11:56 PM

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Doretha
2 months ago
Clopidogrel, the OG platelet inhibitor that needs a little liver love to get the job done. Gotta keep that P450 party going!
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Emeline
25 days ago
Liver enzymes are crucial for activating clopidogrel in ACS.
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Aide
1 months ago
Clopidogrel is metabolized by hepatic P450 enzymes.
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Latosha
1 months ago
Patient needs clopidogrel for PCI, liver enzymes activate it.
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Caitlin
2 months ago
Ha, warfarin as an option? Might as well throw in some leeches while they're at it!
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Maia
5 days ago
User 3: Actually, it's C) Eptifibatide that needs hepatic P450 enzymes for activation.
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Jolene
6 days ago
User 2: No, I believe it's B) Ticlopidine.
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Matt
7 days ago
User 1: I think the answer is A) Clopidogrel.
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Beth
2 months ago
Ugh, I always get these P450 enzyme activation questions mixed up. Time to brush up on my acute coronary syndrome pharmacology.
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Lavonna
5 days ago
C) Eptifibatide
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Arlean
11 days ago
B) Ticlopidine
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Wava
1 months ago
A) Clopidogrel
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Lovetta
2 months ago
I remember learning about the importance of clopidogrel's activation in pharmacology. Looks like I'm ready for this question!
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Kaycee
27 days ago
Sorry, that's incorrect. It's actually Clopidogrel that needs hepatic P450 enzyme activation.
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Glenn
29 days ago
C) Eptifibatide
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Glenna
1 months ago
That's correct! Clopidogrel needs to be activated by hepatic P450 enzymes.
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Alexia
1 months ago
A) Clopidogrel
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Rasheeda
2 months ago
I'm not sure, but I think it's C) Eptifibatide.
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Luther
2 months ago
Clopidogrel is the correct answer. It's a prodrug that requires metabolic activation by hepatic P450 enzymes to become its active form.
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Noel
2 months ago
I agree with Geoffrey, Clopidogrel needs hepatic P450 enzymes for activation.
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Geoffrey
3 months ago
I think the answer is A) Clopidogrel.
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