NABP Exam NAPLEX Topic 10 Question 81 Discussion

Actual exam question for NABP's NAPLEX exam

Question #: 81
Topic #: 10

[All NAPLEX Questions]

Which of the following is true regarding extent of absorption of drugs?

AAfter oral ingestion of drugs, the absorption of drug may be incomplete

BDrugs which are too lipophilic cannot cross the lipid cell membrane

CDrugs which are too hydrophilic are not soluble enough to cross the water layer adjacent to the cell

DP-glycoprotein is an efflux transporter which is present in the enterocytes and it enhances the absorption of drug

EGrape juice activates P-glycoprotein leading to substantial inhibition of absorption of drugs

Show Suggested Answer

Suggested Answer: A

The dihydropyridine drug -- nifedipine -- is the active ingredient found in the medicine Adalat. Nifedipine is used to treat angina, Reynaud's phenomenon and hypertension. It is also used as a tocolytic agent in premature labor.

by Yoko at May 09, 2024, 07:01 AM

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Adell

2 months ago

Option E is just plain funny. Grape juice as a drug absorption inhibitor? Maybe they should add wine as a choice too, for a more 'spirited' exam experience.

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Whitley

8 days ago

C) Drugs which are too hydrophilic are not soluble enough to cross the water layer adjacent to the cell

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Keneth

10 days ago

B) Drugs which are too lipophilic cannot cross the lipid cell membrane

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Brandon

1 months ago

A) After oral ingestion of drugs, the absorption of drug may be incomplete

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Haydee

2 months ago

D is incorrect. P-glycoprotein is an efflux transporter that actually reduces drug absorption, not enhances it. Grape juice inhibiting P-glycoprotein could potentially increase drug absorption, not decrease it.

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William

2 months ago

I'm not sure about B and C. Shouldn't the drug's physicochemical properties be balanced to achieve optimal absorption? Maybe I need to review my lipophilicity and hydrophilicity concepts.

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Willie

4 days ago

User 4: D) P-glycoprotein is an efflux transporter which is present in the enterocytes and it enhances the absorption of drug

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Ciara

21 days ago

User 3: I'm not sure about B and C. Shouldn't the drug's physicochemical properties be balanced to achieve optimal absorption? Maybe I need to review my lipophilicity and hydrophilicity concepts.

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Dortha

25 days ago

User 2: E) Grape juice activates P-glycoprotein leading to substantial inhibition of absorption of drugs

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Royce

2 months ago

User 1: A) After oral ingestion of drugs, the absorption of drug may be incomplete

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Lourdes

2 months ago

I agree with A. Incomplete absorption is a common phenomenon, and it's crucial to understand the factors affecting it, like you mentioned.

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Kent

2 months ago

User 2: Yeah, it's important to consider factors affecting absorption.

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Asuncion

2 months ago

User 1: I think A is true, incomplete absorption happens often.

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Zoila

2 months ago

Option A is correct. Drug absorption can indeed be incomplete after oral administration due to various factors like first-pass metabolism, drug efflux transporters, and physicochemical properties of the drug.

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